Christina Applegate Shares Her Misdiagnosis Journey

Christina Applegate recently disclosed an unexpected revelation regarding her health. In 2021, the actress known for her role in “Married… with Children” shared that she had been diagnosed with multiple sclerosis (MS), a challenging neurological condition. However, in a recent episode of her podcast “MeSsY,” co-hosted with Jamie-Lynn Sigler, Applegate revealed she was misdiagnosed and remains uncertain about the source of her health problems.

During the podcast aired on Tuesday, Applegate expressed her confusion, stating, “I’m back at square one that I don’t know what’s going on with me.” The diagnosis had initially been made after several tests suggested she had MS, similar to Sigler, whose nerves’ protective covering was affected. However, a subsequent visit led her doctor to inform her, “Um, congratulations. You don’t have MS.”

Despite what might appear as good news, Applegate admitted she feels uncertain. “You don’t get misdiagnosed and then all of a sudden I’m better, right?” she questioned. Her condition has not improved; in some respects, she feels worse.

Christina Applegate (L) speaks onstage during the Light Up The Blues 7 Concert celebrating Autism Speaks’ 20th Anniversary at the Greek Theatre on April 26, 2025, in Los Angeles, California. (Photo by Kevin Winter/Getty Images)

The Los Angeles native continues to experience every symptom associated with MS, yet the cause remains elusive. She voiced her concern about disappointing those who connected with her struggle and losing the purpose that drove her to advocate for MS awareness. “I don’t have a reason and it’s very unnerving and it’s very confusing for me,” she said.

In March, Applegate candidly discussed her thoughts on mortality, revealing she had prepared for her future by purchasing burial plots. Her experience, marked by moments of good spirits and a significant hospital stay, highlights her ongoing challenges despite the changed diagnosis.