The Threat to Research: Funding Cuts Face Criticism

A desert lizard known as the Gila monster can survive long periods without food. In the 1990s, Dr. John Eng, intrigued by its ability to maintain stable blood sugar during these fasts, studied its venom. He isolated a molecule resembling a human gut hormone that lasted significantly longer.

This discovery paved the way for GLP-1 drugs like Ozempic and Wegovy, reshaping treatments for diabetes and obesity, and holding potential for heart disease. These innovations could save many lives. Remarkably, Dr. Eng’s work required minimal funding.

However, the system supporting such medical breakthroughs is under threat. In 2025, the Trump administration halted billions in research grants. Despite courts releasing some funds and Congress opposing cuts, control over finances remains limited. Funding for research grants has declined significantly in recent months.

The Trump administration proposes further cuts, demanding that grants align with political priorities, potentially slowing down approval processes.

This situation has already affected future scientists. Graduate programs at major universities reduced admissions, impacting emerging talents. Cancer researcher Rachael Sirianni expressed fears over securing funding for vital research on treatments for children’s brain tumors.

Reduced support stifles exploration of unconventional questions, crucial for medical progress. Historical breakthroughs, like rapamycin from Easter Island soil, or CRISPR gene editing inspired by yogurt bacteria, highlight the importance of funding diverse research. CRISPR now addresses diseases like sickle cell and even corrected a genetic defect in an infant born with a lethal mutation in 2025.